Impulsivity and behavioral response inhibition represent core transdiagnostic constructs in behavioral neuroscience and translational psychiatry, central to ADHD, autism, borderline personality disorder, and schizophrenia. Despite decades of research, the literature fails to adequately characterize cognitive control dimensionality, limiting differential diagnosis and precision psychiatry. This quantitative Research Domain Criteria (RDoC) study discriminated and dimensionalized neurobiological and neuropsychological endophenotypes through deep phenotyping, guided by Barkley's inhibitory deficit theory, to enable computational neuroscience applications.
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Read “Neurobiological and Neuropsychological Deep Endophenotypes of Behavioral Response Inhibition: RDoC Empirical and Mathematical AI Feature Engineering,” a dissertation authored by John E. Wehrli, published by ProQuest Dissertations & Theses.